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Sequences and details of primers and assay probes are provided in the Supplementary Table S2

If your provider prescribes Zepbound off-label for weight loss and submits a prior authorization request to TRICARE, the request will be denied with the reason code "non-covered indication per 42 USC 1395w-102(e)(2)(A)." No amount of medical necessity documentation changes this outcome

Trials such as SURPASS-3 and SURPASS-4 compared tirzepatide to insulin therapies, demonstrating superior weight reduction and glycemic outcomes (45)

1mg per dose Primary Benefits Provides direct anabolic signaling through IGF receptors, promoting muscle protein synthesis, tissue repair, and metabolic optimization independently of GH