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The Role of Semaglutide and Tirzepatide in the Body Semaglutide and Tirzepatide are medications that mimic the effects of glucagon-like peptide-1 (GLP-1), a hormone that regulates blood sugar levels and appetite
Hartmann says that the need for them to do so is increasing following legal initiatives such as the Cross-Border Healthcare Directive (which came into force in October 2013, and has an HTA component informed by the EUnetHTA)
The SURMOUNT-1 trial demonstrated significant weight loss, with patients losing approximately 15-21% of their body weight at the 15 mg dose over 72 weeks, depending on the statistical method used
The drugs mechanism of action first exploits the GLP-1 pathway to restrict hunger, thereby reducing food intake
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