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These factors add complexity to OVX-focused preclinical studies of exogenous androgens, SARMs, or ARKO in females, as it is difficult to isolate tissue phenotype deficits to a mechanism of action from either lost testosterone-AR, E2-ER, or progesterone-PR activity

The agencys position is that BPC-157 has no approved human clinical trials proving its safe and effective at the doses people were actually using

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Most of the research on BPC-157 has been conducted in animal studies , primarily in rats and mice