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Mast cells generate histamine in an allergic reaction, and when suffering from MCAS, the levels can rise in such a way that the symptoms are exacerbated, mainly: Because the symptoms of MCAS and histamine intolerance are similar, it will be hard to tell the difference between the two

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In the case of the skin, glutathione is used as a protective barrier

All statistical analyses were conducted using the TwoSampleMR (for extracting genetic associations where publicly available and harmonization), MendelianRandomization and MRPRESSO (for deriving MR estimates), and meta package (for assessing heterogeneity in sex differences) in R (version 4.0.1, R Foundation for Statistical Computing, Vienna, Austria)

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