Studies suggest comparative efficacy between retinol and plant-based alternatives can be evaluated through transcriptomic analysis and collagen synthesis assays in both 2D and 3D skin models
Nrf2 activation regulates antioxidant responses to modify cellular redox states from predominantly pro-oxidant to antioxidant, and, in an antioxidant environment, macrophage phenotypes shift from M1 pro-inflammatory to M2 anti-inflammatory, reducing the probability of cytokine storms, ARDS, and lethality (Tan et al., 2016
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