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The company reported over 270,000 GLP-1 subscribers by late 2024
When GLP-1 is secreted from L-cells through the TGR5 agonist, it stimulates GLP-1R in enterochromaffin cells and induces serotonin or 5-hydroxytryptamine (5-HT) secretion from these cells
Introduction# CagriSema (cagrilintide + semaglutide, Novo Nordisk) and tirzepatide (Eli Lilly) represent the pinnacle of next-generation obesity pharmacotherapy, both achieving approximately 20% weight loss through different dual-mechanism approaches
The clear contrast you draw between tirzepatide and semaglutide on normoglycemia, HbA1c, weight loss, and insulin sensitivity really underscores the potential of dual incretin agonism to modify the metabolic trajectory in obesity with prediabetes
autosomal dominant) Psammomatous melanotic schwannoma: Mass effects Lentigines (65%) of face, lips, caruncle, and female genitalia Myxomas of heart (65%), skin (25%), breast (20%) Blue nevi of extremities and trunk Endocrine overactivity Cushing syndrome (25%): Pigmented nodular adrenocortical disease Acromegaly: Pituitary adenoma, mammosomatotrophic type Precocious puberty (30%): Large cell Sertoli tumor of testis Treatment Surgical approaches Resection with tumor-free margins for all lesions Prognosis Benign Recurrence in subtotal resection Malignant Metastasis Distinguish metastases from 2nd primary Prognosis same in conventional and psammomatous variants 15% die of tumor IMAGE FINDINGS MR Findings CT Findings Calcification/ossification on CT in some psammomatous tumors MACROSCOPIC FEATURES General Features 0.5-26 cm (median: 5 cm) Circumscribed Round to sausage-shaped Spinal nerve root tumors: Dumbbell-shaped Occasionally lobulated or cystic No encapsulation Occasionally thin collagen layer with soft tissue invasion Effects of bone Erosion (benign tumors) Invasive destruction (malignant tumors) Cut surface gray to tar black Infrequently cystic Occasional hemorrhage or necrosis Occasional subcapsular grittiness (psammomatous variant) Soft to rubbery
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