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This could result in dangerously high doses
Zeng F, Lai M, Li Q, Zhang H, Chen Z, Gong S, Liu X, Liu B (2023) Anti-oxidative and anti-aging effects of mannoprotein-rich yeast cell wall enzymatic hydrolysate by modulating gut microbiota and metabolites in Caenorhabditis elegans
As of 2026, no peer-reviewed human clinical trials on FOXO4-DRI have been published
The published record does not establish a human-use protocol
This broad genomic influence suggests mechanisms beyond simple receptor activation, potentially explaining the peptide's diverse cognitive and neuroprotective effects
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