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BPI Labs received an FDA warning letter in March 2025 for distribution of epinephrine nasal solution that the FDA had previously warned health care professionals not to use because of serious medication-error risk if confused with injectable epinephrine

Intramuscular injection is also reported

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Collectively, such therapies have been dubbed nutrient-stimulated hormone-based treatments because they mimic the action of hormones that are released or function when specialized sensor cells in the digestive tract detect food intake

Odetayo AF, Olayaki LA (2022)