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By reducing the water content of the tissue surrounding the cerebral hematoma, enhancing the deformability of red blood cells, improving brain edema, and inhibiting the levels of MMP9 mRNA and AQP4 mRNA in brain tissue, the integrity of the BBB is protected (Zheng et al., 2014
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Upon binding, it initiates a signal transduction pathway involving the cyclic adenosine monophosphate (cAMP) and protein kinase A (PKA) systems
Zhou et al
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