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iLISI was calculated using the first 20 principal components before Harmony correction and the first 20 Harmony-corrected dimensions after integration, with dataset identity used as the batch label
It has also been shown to lower homocysteine levels, a molecule linked to inflammation and cognitive decline, with longitudinal studies linking optimal B12 levels with improved cognitive function, mood and reduced risk of neurodegenerative disease
This review highlights that age-related declines in brain GSH may contribute to cognitive decline by disrupting mitochondrial, vascular, and immune regulation
Long-term effects in humans are unknown
Gut symptoms often improve within 2 to 4 weeks
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