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6.2 Irisin and the endocrinology of exercise Irisin, a peptide cleaved from the transmembrane protein FNDC5 and released from skeletal muscle during exercise, represents a parallel and more controversial example of muscle-derived endocrine signaling

The remaining four strains were excluded for the following reasons: (1) KCCM 12485 ( S

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This knowledge deficit likely stems from inherent physicochemical challenges including: low natural abundance in plant matrices, low molecular polarity, poor aqueous solubility, slow dissolution kinetics, and consequently low bioavailabilityall of which collectively impede comprehensive ADME profiling

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