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Indeed, during active IBDs, the expression of enterotoxigenic Bacteroides fragilis, which is a metalloprotease-producing bacteria, is increased, thus causing inflammatory diarrhea

If you are wondering about drinking alcohol on semaglutide or tirzepatide , know that it can worsen constipation significantly in addition to its other interactions

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As for the sensation, its good to be prepared for a little discomfort

PubMed Anderson RA