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In addition, there are still many problems with nanoparticle drug therapies targeting immune cells for tumors, including but not limited to the following: (1) A large number of products are difficult to reproduce due to the synthesis and post-modification procedures of nanoparticles, especially highly engineered nanoparticles, and this also result in increased costs (246)

PMID: 118 LawAMKValdes-MoraFGallego-OrtegaD

Immediate oxygen and glucose deprivation rapidly deplete ATP, disrupt the transmembrane ionic gradients, increase glutamate excitotoxicity, and overload mitochondrial with calcium

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These side effects will have to be taken into consideration when determining appropriate dosing for chronic disorders