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Nature 346 , 866868 (1990)

At high concentrations, nitric oxide can inhibit heme insertion into hemoglobin and alter liver enzyme activity

Advances in Clinical Chemistry, Volume 82

It works internally via gene activation, not surface exfoliation

In mice, the bulk of the metabolic improvement seen upon FGF21 treatment derives from centrally mediated weight loss, whereas FGF21 analogs elicit limited weight loss in humans