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TGR5 is the target of different BAs, but the most potent endogenous agonist has shown to be lithocholic acid (LCA) and its taurine conjugates with activity at nanomolar concentrations (273, 339)
in vitro with chemically reactive metabolites derived from several drugs displaying idiosyncratic toxicity, including troglitazone, acetaminophen, clozapine, and diclofenac (Okada et al., 2011
The practical difference between single and split dosing remains unclear from available research, so personal experimentation within recommended total daily doses is reasonable
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