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& Furney, S

The liver is the major organ affected by the toxicity of iron and typically is the first organ to fail

J Altern Complement Med 19:13440

2.3.3 Ferroptosisis and inflammation Unlike immunologically silent apoptosis, ferroptosis is immunogenic, as cells undergoing ferroptosis release cell contents including DAMPs and alarm proteins due to plasma membrane rupture, amplifying cell death and triggering a cascade of inflammation-related responses ( 3 Ferroptosis inducers and inhibitors Ferroptosis inducers and inhibitors act by modulating key mechanisms in the ferroptosis pathway mentioned above to respectively promote or inhibit iron-dependent cell death (108)

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