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Total glutathione concentrations decreased by approximately 70% after 18 hr incubation with 10 mM BSO and increased by approximately 25% after incubation with 2.5 mM cysteine, and these effects were not due to impacts on A6 viability (Figure A3)
As depicted in Figure 3D, AICAR treatment significantly inhibited the phosphorylation of PARP-1 while it increased the ABCA1 protein level
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While the results have been mixed, the potential for melanocortin-based therapies to address a variety of dermatological and systemic conditions remains an area of active investigation
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