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To compare the effects of paraxanthine against caffeine and the impact of age, young 8-week-old (YOUNG) and aged 16-month-old (OLD) rats were evenly divided into four groups ( n = 8 per group): (i) vehicle control (CON), (ii) low-dose paraxanthine (PXN LOW), (iii) high-dose paraxanthine (PXN HIGH), and (iv) high-dose caffeine (CAF HIGH)
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The crossover study of an oral methionine load by Bellamy et al (1998) also supports the view that elevated homocysteine levels may promote vascular disease by impairing flow-mediated endothelium dependent vasodilation
Indeed, the thermolabile MTHFR defect and heterozygosity for CBS deficiency might increase vascular disease risk by respectively increasing the amounts of dietary folate and vitamin B 6 that are needed to prevent hyperhomocysteinemia
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