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Small spleen peptides prevent development of psoriatic arthritis via restoration of peripheral tolerance

Avoid repeated freeze-thaw cycles, which can promote aggregation in lipidated peptides

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Preclinical studies using T4 (including the RGN-259 ophthalmic clinical trials) have not identified significant adverse events at therapeutic doses

NICE guidance on the assessment and management of overweight and obesity in adults (currently CG189 and associated updates) provides the overarching framework, alongside the technology appraisals for semaglutide 2