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Research14 min read De Novo Peptide Design: From Computer Screen to Clinical Trial How computational peptide design transforms protein engineering from computer algorithms to clinical trials

Freezing a reconstituted peptide solution is not recommended, because the freeze-thaw cycle can cause aggregation and denaturation that reduces potency

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For vitamin B deficiency (e.g., pernicious anemia), a common regimen is to begin with frequent intramuscular injections to replenish body stores

101 Extravasation of leukocytes is achieved by three fundamental processes: Adhesion of integrin to VCAM and ICAM, which are overexpressed in response to stress cytokines secreted by glial cells Extravasation adhesion signals a conformational change in the actin cytoskeleton, which creates a window in the BBB for extravasation of cells