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Ferroptosis and acute kidney injury (AKI): molecular mechanisms and therapeutic potentials

No completed randomized controlled human trial

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Interestingly, metabolic disorders and elevated oxidative stress disturb the insulin-associated signaling within the ovary and can dysregulate the dynamics of the ovarian function through the impair the ovarian reserve, survival, and quality of the eggs [15]

Biguanide-derived neuroprotective agent (metformin) To mitigate neuroinflammation and mitochondrial dysfunction in PD, metformin was encapsulated into PLGA, which were further coated with BV2 microglial cell membranes to enhance the targeting efficiency to neuroinflammatory sites (BV2-metformin-loaded PLGA) for intranasal administration 19