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Physical activity promotes angiogenesis, increases IGF-1 levels, activates cellular proliferation pathways, and creates an overall growth-promoting environment in the body

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Interestingly, the treatment demonstrated dose-dependent therapeutic effects, with moderate dosages proving more effective than high doses (1,000 mg/kg), possibly due to pharmacodynamic principles, where excessive concentrations saturate biological pathways and diminish therapeutic outcomes (Tyagi et al., 2025