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Cagrilintide is a long-acting amylin analogue that reduces appetite and slows gastric emptying, whilst retatrutide is a triple GLP-1, GIP, and glucagon receptor agonist designed to reduce appetite and increase energy expenditure

Bibcode:2020Sci...369.1490K

Where insulin handles the cellular glucose disposal, amylin handles the meal-related slowdown signals appetite suppression, slowed digestion, and counter-glucagon effects