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Abbas et al., 2009
Tirzepatide produces significantly greater weight loss, averaging 2022.5% of body weight compared to semaglutide's 1517.4% across clinical trials
Supplements/meds: magnesium citrate or a stool softener for constipation
Slowing the administration rate (inject over 6090 seconds instead of 30 seconds) and ensuring the formulation is at room temperature before injection reduces peak concentration and histamine response
Plus, your provider is available between appointments via messaging if you have questions or need support
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