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GHK-Cu is a copper-binding peptide known to stimulate collagen production, promote angiogenesis, and activate genes associated with tissue remodeling and wound healing, making it a powerful agent in skin and muscle recovery

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At the same time, IGFBP-3, the binding protein of IGF-1, can regulate the IGF-1 activity in tissues to some extent, and the molar ratio of IGF-1/IGF-BP-3 can unveil the number of IGF-1 with biological activity [30, 31, 32]

At the functional level, co-transfection of D 2 Rs with D 4.4 Rs, but not D 4.7 Rs, led to an increase in MAPK signaling (52, 57), which would seem opposite to the expected D 4.7 R gain of function

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