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For instance, HSPA2 is upregulated in the testicular tissue of rats with varicocele (Afiyani et al., 2014), whereas clinical samples from patients with varicoceles show reduced HSPA2 expression (Panner Selvam and Agarwal, 2021)
The functional consequence in animal models is synergistic rather than additive GH output: GHRH-R priming increases the pool of releasable GH vesicles, and GHS-R1a co-stimulation then drives a larger amplitude pulse than either receptor produces alone
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