Notably, caloric restriction (CR) and moderate weight loss (approximately 510%) improve insulin sensitivity despite the accompanying loss of muscle mass, and the observed reduction appears to result primarily from increased proteolysis rather than reduced protein synthesis
GLP-1 medications are powerful tools for weight loss and blood sugar control, but they come with trade-offs
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Further, GLP-1RA therapy was associated with reduced risks of stroke or TIA, MI, VTE, PE, all-cause mortality, hospitalization, and ED visits in participants with T2D
It can also support a healthy immune response and encourage tissue health