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Blundell, J., et al., Effects of once-weekly semaglutide on appetite, energy intake, control of eating, food preference and body weight in subjects with obesity

The idea of regulating glucose levels through DPP-4 inhibition was initially conceived 25 years ago, paving the way for the development of different DPP-4 inhibitors and their widespread clinical utilization [38]

It warns that patients may wrongly read the resulting loss of effect as treatment failure rather than a medication problem, listing reduced appetite suppression, inconsistent glucose control, and metabolic plateaus among the signs

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Kamat, Manmohan et al