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One of the issues with constipation is that it makes it easy for toxins to go back into the body , instead of leaving the body the way they are supposed to
doi: 10.1038/s41598-018-24240-2 295 PitaksaleeRBurskaANAjaibSRogersJParmarRMydlovaKet al
doi:10.1016/0009-8981(83)90291-7
A randomised, double-blind, placebo-controlled trial of metformin on myocardial efficiency in insulin-resistant chronic heart failure patients without diabetes
(March 2013)
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