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The addition of glucagon receptor agonism to the GLP-1/GIP dual mechanism significantly increases energy expenditure and fat oxidation, producing weight loss potential that exceeds even tirzepatide

The short duration of action needed to be addressed to exploit the promising effects of GLP- 1 for the development of a clinically beneficial drug

no separate PDA trial base as of April 2026

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The financial cost of tissue sampling was higher than swabbing, taking into account antibiotic usage, hospitalisation, and other costs