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The reactive arm identifies proteins that escape productive folding or become damaged over time and routes them into clearance or repair pathways, primarily the ubiquitinproteasome system and lysosomal autophagy (Fig

One study used supplemental precursor amino acids cysteine and glycine over a 14-day period to successfully restore glutathione synthesis and lower oxidative stress and oxidant damage

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In a study by Tomosugi et al