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Ishida K, et al

The kidneys help get rid of extra B12

Across GLP-1 trials, about 60% of lost weight returns within the first year and roughly 75% returns over the longer curve, with the fastest regain in the early months. The semaglutide extension follows the same direction. The pattern reflects removal of appetite suppression after major weight loss

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In a randomized, double-blind, placebo-controlled trial published in The Lancet, obese patients receiving Tesofensine experienced substantially greater weight reductions compared to those on a placebo