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It was first isolated in 1977 by Swiss researchers Guido Schoenenberger and Marcel Monnier, who identified it in the cerebral venous blood of rabbits whose brains had been electrically stimulated to induce slow-wave sleep

Tbr2 is essential for hippocampal lineage progression from neural stem cells to intermediate progenitors and neurons

We dissect how these rationally engineered platforms overcome the unique physical and cellular barriers of the osteosarcoma TME, with a critical emphasis on the severe translational hurdles, such as protein corona formation and in vivo stability, that limit clinical progression

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the liver generates it