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Methods In trial 1, 52 healthy subjects received lisinopril (20 mg single dose) or warfarin (25 mg single dose) with subsequent coadministration with SNAC alone (300 mg single dose), followed by oral semaglutide 20 mg once daily (steady state)
Patients with chronic limb-threatening ischemia and those with obesity had the largest improvement in outcomes
17% patients had eGFR 300 mg/g) [49]
[17] [18] Whether pharmacological weight loss with GLP-1 or dual incretin receptor agonists confers similar benefits remains an important research question
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