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Benton CB, Khan M, Nogueras Gonzlez GM, Nazha A, Piao J, Ning J, Aung F, Jabbour E, Kadia TM, Borthakur G, Ravandi F, Pierce S, Komrokji RS, Steensma D, DeZern A, l Roboz G, Sekeres M, Andreeff M , Kantarjian H, Garcia-Manero G
Protein needs vary
Formulation development focuses on maintaining peptide stability through pH optimization, addition of stabilizing agents, and appropriate packaging systems
According to the SmPC, treatment continuation depends upon achieving and maintaining adequate weight loss (at least 5% of initial body weight after 12 weeks at the maintenance dose of 3.0 mg daily)
If butyrate levels fall short, the gut barrier may become less stable, motility can become unpredictable, and the colon's immune environment may shift
