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That flat selectivity profile is precisely what keeps MT2 useful in vitro: it serves as the positive-control full agonist against which subtype-selective ligands are benchmarked, and it is the parent scaffold for a large derivative family generated by single substitutions at positions 6, 7 and 9, including the MC3R/MC4R antagonist SHU-9119
In addition, GLP-1 indirectly inhibits glucagon secretion by stimulating release of insulin and somatostatin or by directly engaging with GLP-1R found on cells of the pancreas (2)
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