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In the 72-week SURMOUNT-5 trial described in this article, average weight reduction was 20.2% with tirzepatide and 13.7% with semaglutide among adults with obesity without type 2 diabetes

Potential Side Effects and Safety Questions Per the brand's own FAQ content, side effects depend on which specific therapy you're using, and the brand names mild GI upset, headache, and injection-site reactions as possibilities for some options

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Drinking fluids and resting usually help

Its primary physiological role involves stimulating insulin secretion from pancreatic beta cells in a glucose-dependent manner, which has made GLP-1 receptor agonists valuable therapeutic agents for type 2 diabetes mellitus