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By comparison, the tirzepatide in Mounjaro and Zepbound works on both the GLP-1 and GIP pathways

In the first half of 2025, Mounjaro sales alone approached several billion dollars, putting it on track to challenge Novos Wegovy/Ozempic for the highest sales in the weight loss/diabetes class

The risk may be higher when appetite is very low, protein intake drops, and resistance training is absent

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