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Aggregated panel responses formed the basis of the final recommendations, which are intended to provide clinicians an experience-driven guidance for practical application

[17] [18] [19] Biological functions [edit] Circadian rhythm [edit] In mammals, melatonin is critical for the regulation of sleepwake cycles, or circadian rhythms

It is normally involved in the metabolism of every cell of the human body, especially affecting DNA synthesis and regulation, but also fatty acid metabolism and amino acid metabolism

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Dysplastic naevi Clinically enlarged flat naevi, or naevi that show atypical cellular or architectural features microscopically