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The APR-246 structural analog PRIMA-1 has been shown to induce apoptosis through the JNK pathway, which synergizes with the apoptotic pathway induced by Trx1 oxidation via ASK1 release 45
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We assume that the flexibility of the polypeptide backbone and the targeting ligands could help the uptake and permeability of the 3-PLGs with similarly greater size at the BBB model
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