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showed that DEX increased the expression levels of SLC7A11 and GPX4 and protected H9C2 cells from hypoxia/reoxygenation injury through the AMPK/GSK-3/Nrf2 axis [233]

Peptide Therapy: What Is It & Why Does It Matter

Lenmeldy is the first FDA-approved gene therapy for MLD, which is caused by a deficiency of the arylsulfatase A (ARSA) enzyme, a state that leads to a buildup of fatty substances in the cells

While safe at therapeutic doses of up to 4 grams per day for adults, acetaminophen overdoses, either accidental or intentional, are the leading cause of acute liver failure in the United States, accounting for some 56,000 emergency room visits, 2,600 hospitalizations and nearly 500 deaths annually[2, 3]

Ethics declarations Ethics approval All experimental procedures were approved by the Institutional Animal Ethics Committee (IAEC) of Girijananda Chowdhury Institute of Pharmaceutical Science (Approval No: GIPS/IAEC/M.PH/PRO/25/2022), and the protocols were by CPCSEA guidelines