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Rare but serious: allergic reactions

Compounded medications have not been approved by the FDA for safety, effectiveness, or quality and should only be used when FDA-approved medications are unavailable

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Oral tirzepatide options , tirzepatide drops , and tablet formulations provide the same active medication without the subcutaneous delivery that causes local reactions

Conversely, in a recent randomized, double-blind, placebo-controlled study involving twenty healthy volunteers, a once-weekly injection of a GLP-1R agonist, dulaglutide, for three weeks did not influence HPA axis activity, showing no significant effects on circadian rhythms of blood or salivary cortisol secretion, and the level of this hormone also was not changed after the dexamethasone suppression test in comparison with the placebo-receiving group [78]