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Your body doesnt always convert it wellespecially if you have a genetic variation in an enzyme called DHFR (dihydrofolate reductase)

Therefore, we found that the enhanced insulinotropic effect of exendin-phe1 in vitro is recapitulated in a mouse model of T2D, suggesting that GLP-1R trafficking plays a role in determining the responses to therapeutic GLP-1R agonists in vivo