doi: 10.3389/ftox.2025.1543374 Received 11 December 2024 Accepted 10 January 2025 Published 27 January 2025 Volume 7 - 2025 Edited by Konrad Andrzej Szychowski, University of Information Technology and Management in Rzeszow, Poland Reviewed by Jae-hyeon Park, National Institute on Aging (NIH), United States Van Thi Ai Tran, Sungkyunkwan University, Republic of Korea Updates Copyright 2025 Wang, Rong, Niu, Leng, Wang, He, Qi, Zhao and Li
doi: 10.1089/pho.2007.2062
The peptide's activation of ERK1/2 and downstream transcription factors including Egr-1 drives expression of collagen synthesis genes while its enhancement of cellular migration ensures efficient fibroblast recruitment to sites requiring matrix deposition, creating optimal conditions for rapid yet organized tissue reconstruction
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When these demands exceed available biochemical reserve, mitochondrial energy and recovery from stress may become less efficient