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Those selected will receive weekly injections of either semaglutide or a placebo over a 24-week treatment period, followed by a subsequent safety follow-up phase

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Such buffering could for example be mediated by activation of the Nrf2-Keap1-ARE pathway, which has been shown to be increased after polyphenol supplementation which in turn induces the expression of phase II detoxifying enzymes, responsible for reducing endogenous toxic metabolites [65]

The practical limitation is patient training

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