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The included preclinical studies demonstrated consistently positive effects across diverse injury models including tendon rupture, ligament tears, muscle injuries, bone fractures, and combined soft tissue trauma
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The DPPOS 15-year data showed that metformin continued to confer a 17% reduction in cumulative diabetes incidence compared with placebo, without any safety signals emerging over long-term use [5]
Chen, J., Jiang, X., Carroll, S
Guo et al., 2022)
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