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This dysregulation can manifest as esophageal dysmotility, gastroparesis (delayed gastric emptying), intestinal enteropathy, constipation, or diarrhea
Microbiota-based interventions to enhance GLP-1 RA efficacy (probiotics, prebiotics, postbiotics) Given the bidirectional interplay between GLP-1 RAs and the gut microbiota, increasing attention has been directed toward microbiota-targeted strategies to address key clinical challenges, such as inter-individual response variability and substantial weight regain after treatment discontinuation
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Por lo tanto, la alternativa a los aGLP-1 seran los iSGLT-2, que adems de reducir los eventos MACE, disminuyen la mortalidad, tienen efectos beneficiosos en la prevencin de hospitalizacin por insuficiencia cardiaca y cuentan con ensayos especficos en insuficiencia cardiaca y ERC
Fluid retention: May include edema, arthralgia, and carpal tunnel syndrome
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