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No adverse effects were reported, but rigorous, large-scale trials are lacking, according to NIH
doi: 10.1111/j.1528-1167.2008.01821.x, 35
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Brain and Cognitive Support: Sharpen Your Mind Protecting neurons from oxidative stress means better brain health
Schisandra chinensis lignans suppressed the phosphorylation of key signaling molecules, including IB kinase alpha/beta (IKK/), inhibitor of nuclear factor kappa-B alpha (IB), protein kinase B (Akt), TANK-binding kinase 1 (TBK1), ERK, p38, JNK, NF-B (p65), c-Jun, and interferon regulatory factor 3 (IRF3), thereby disrupting the IKK//NF-B, MAPK/AP-1 (c-Jun) and TBK1/IRF3 pathways, which play pivotal roles in inflammation [32]
