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Both 25-hydroxylases (CYP2R1 and CYP27A1) were expressed in the liver, while CYP27A1 expression was seen only in cultured hepatocytes (FL83B mouse hepatocyte cell line)
This natural origin is part of why GHK-Cu is a recurring subject in research on tissue remodeling and cellular aging, distinguishing it from fully synthetic peptides that lack a native counterpart in the body
Understanding concentration relationships prevents these mistakes
That said, extensive research has been conducted on similar peptides, and no adverse side effects have been seen
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