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A 2011 clinic trial indicated that oral and transdermal glutathione supplementation has a positive effect on glutathione levels
At 25C (room temperature), dissolved GSH in aqueous solution oxidizes at a rate of approximately 25% per week
It is not approved by major health authorities for medical use, and its safety, dosage, and long-term effects are not well established
For example, in patients with metastatic breast cancer, TOPI mutations have emerged as a mechanism of acquired resistance after treatment TOPI inhibitor-based ADCs, conferring resistance to a second ADC with a similar TOPI inhibitor payload 39
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